Research Progress
- Oxidation-responsive OEGylated poly-L-cysteine and solution properties studies
- Effects of the surface charge on the stability of PEG-b-PCL micelles: simulation of the interactions between charged micelles and plasma components
- Supramolecular Hydrogels Assembled from Nonionic Poly(ethylene glycol)-b-Polypeptide Diblock Containing OEGylated Poly-L-glutamate
- Surface-Induced Hydrogelation Inhibits Platelet Aggregation
- Stimuli-responsive polypeptide materials prepared by ring-opening polymerization of α-amino acid N-carboxyanhydrides
- Effects of molecular weight on thermal responsive property of PEGylated poly-L-glutamates
- Facile Synthesis of Dendrimers Combining aza-Michael Addition with Thiol-yne Click Chemistry
- Peptide Hydrogels Assembled from Nonionic Alkyl-polypeptide Amphiphiles Prepared by Ring-Opening Polymerization
- SYNTHESIS OF TOOTHBRUSH COPOLYPEPTIDES BASED ON POLYLYSINE BACKBONE
- One-step synthesis of water dispersible silica nanoplates
- Conformation-specific Self-assembly of Thermo-responsive Poly(ethylene glycol)-b-polypeptide Diblock Copolymer
- Coassembly of Poly(ethylene glycol)-block-Poly(glutamate sodium) and Gemini Surfactants with Different Spacer Lengths
- Thermoresponsive Oligo(ethylene glycol) Functionalized Poly‑L‑cysteine
Effects of the surface charge on the stability of PEG-b-PCL micelles: simulation of the interactions between charged micelles and plasma components
Effects of the surface charge on the stability of PEG-b-PCL micelles: simulation of the interactions between charged micelles and plasma components
Polym.Chem.,2014,5,1720-1727.
Yaoming Wan, Zhihua Gan*and Zhibo Li*
We reported the effects of the apparent surface charge on the enzymatic degradation behavior of PEG-b-PCL micelles. We simulated the interactions between charged micelles and plasma components and investigate the stability of surface charged micelles in the presence of BSA. We synthesized three types PEG-b-PCL di-blocks containing CH3O, NH2, and COOH groups, respectively, at the end of the PEG block. These copolymers can self-assemble into uniform micelles bearing different surface charges. The surface charge of micelles can be simply adjusted by changing the feed ratio of NH2-PEG-b-PCL and COOH-PEG-b-PCL. Mixed charged micelles showed good stability in the presence of BSA and enhanced cell uptake was also expected given the zwitterionic characteristic of the micelle surface. With the tunable surface charge of micelles, we can design novel drug delivery carriers which possess both long blood circulation and efficient cell uptake.
