Research Progress
- Oxidation-responsive OEGylated poly-L-cysteine and solution properties studies
- Effects of the surface charge on the stability of PEG-b-PCL micelles: simulation of the interactions between charged micelles and plasma components
- Supramolecular Hydrogels Assembled from Nonionic Poly(ethylene glycol)-b-Polypeptide Diblock Containing OEGylated Poly-L-glutamate
- Surface-Induced Hydrogelation Inhibits Platelet Aggregation
- Stimuli-responsive polypeptide materials prepared by ring-opening polymerization of α-amino acid N-carboxyanhydrides
- Effects of molecular weight on thermal responsive property of PEGylated poly-L-glutamates
- Facile Synthesis of Dendrimers Combining aza-Michael Addition with Thiol-yne Click Chemistry
- Peptide Hydrogels Assembled from Nonionic Alkyl-polypeptide Amphiphiles Prepared by Ring-Opening Polymerization
- SYNTHESIS OF TOOTHBRUSH COPOLYPEPTIDES BASED ON POLYLYSINE BACKBONE
- One-step synthesis of water dispersible silica nanoplates
- Conformation-specific Self-assembly of Thermo-responsive Poly(ethylene glycol)-b-polypeptide Diblock Copolymer
- Coassembly of Poly(ethylene glycol)-block-Poly(glutamate sodium) and Gemini Surfactants with Different Spacer Lengths
- Thermoresponsive Oligo(ethylene glycol) Functionalized Poly‑L‑cysteine
Thermoresponsive Oligo(ethylene glycol) Functionalized Poly‑L‑cysteine
Thermoresponsive Oligo(ethylene glycol) Functionalized Poly‑L‑cysteine
Xiaohui Fu, Yong Shen, Wenxin Fu, and Zhibo Li*
Macromolecules 2013, 46, 3753−3760
A series of new functional amino acids were prepared in high yield via thiol-ene Michael addition between cysteine and monomethoxy oligo(ethylene glycol) (OEG) functionalized methacrylates (OEGxMA) and acrylate (OEGxA). These OEGylated cysteine derivatives were converted into polymerizable N-carboxyanhydride (NCA) monomers using triphosgene. Subsequent ring opening polymerization (ROP) of these NCA monomers gave a series of OEGylated polycysteine (poly-EGxMA-C or poly-EGxA-C) homopolypeptides. Depending on the chain length of OEG, poly-EGxMA-C or poly-EGxA-C polypeptides displayed different solubility and secondary structure in water. More importantly, the obtained polypeptides can display reversible thermal responsive properties in water when the x value is between 3 and 5. The synthetic strategy represents a new highly efficient method to prepare nonionic functional polypeptides with tunable physical properties.
