Yang Qianfan
Qianfan Yang
Birth: 1981.10 Native Place: Leshan, Sichuan
Contact: yangqf@iccas.ac.cn
Contact: yangqf@iccas.ac.cn
Education and Work experiences
2010.7-present Institute of Chemistry, Chinese Academy of Sciences (ICCAS) Assistant research
2005.9-2010.7 Institute of Chemistry, Chinese Academy of Sciences (ICCAS) Ph. D.
2004.7-2005.9 Institute of Chemistry, Chinese Academy of Sciences (ICCAS) Laboratory assistant
2000.9-2004.7 Beijing University of Chemical Technology (BUCT) B. Sc.
2010.7-present Institute of Chemistry, Chinese Academy of Sciences (ICCAS) Assistant research
2005.9-2010.7 Institute of Chemistry, Chinese Academy of Sciences (ICCAS) Ph. D.
2004.7-2005.9 Institute of Chemistry, Chinese Academy of Sciences (ICCAS) Laboratory assistant
2000.9-2004.7 Beijing University of Chemical Technology (BUCT) B. Sc.
Publications
1. Gai, W., Yang, Q.*, Xiang, J., Yu, L., Guan, A., Li, Q., Sun, H., Shang, Q., Jiang, W., Zhang, H., Liu, Y., Wang, L., Tang, Y.* (2013) Novel Dual-Functional Regulation of a Chair-Like Antiparallel G-quadruplex on Inducing Assembly/Disassembly of Cyanine Dye. Phys. Chem. Chem. Phys., 15, 5758-5761..
2. Gai, W., Yang, Q.*, Xiang, J., Jiang, W., Li, Q., Sun, H., Guan, A., Shang, Q., Zhang, H. and Tang, Y.*, (2013) A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)]4 and cyanine dye 2, 2-diethyl-9-methyl-selenacarbocyanine bromide. Nucleic Acids Res., 41 (4), 2709-2722.
3. Gai, W., Yang, Q.*, Xiang, J., Jiang, W., Li, Q., Sun, H., Yu, L., Shang, Q., Guan, A., Zhang, H. and Tang, Y.*, (2013) A novel signal-amplified strategy based on assembly reactivation for highly specific and sensitive detection of chair-like antiparallel G-quadruplex. Analyst, 138 (3), 798-804. (Hot Article)
4. Gai, W., Yang, Q.*, Xiang, J., Sun, H., Shang, Q., Li, Q., Jiang, W., Guan, A., Zhang, H., Tang, Y.* and Xu, G., (2013) Roles of flanking sequences in the binding between unimolecular parallel-stranded G-quadruplexes and ligands. Chin. Sci. bull., 58, 731-740. (Cover Article)
5. Ng, N., Leverett, P., Hibbs, D., Yang, Q., Bulanadi, J., Wu, M., Aldrich-Wright, J.*, (2013) The antimicrobial properties of some copper(II) and platinum(II) 1,10-phenanthroline complexes. Dalton Trans. 42, 3196-3209.
6. Yang, Q., Xiang, J., Yang, S., Li, Q., Zhou, Q., Guan, A., Lin, L., Zhang, X., Zhang, H., Tang, Y. and Xu, G. (2010) Verification of Intramolecular Hybrid/Parallel G-quadruplex Structure under Physiological Condition by Using Novel Cyanine Dye H-aggregates: both in Solution and on Au Film. Anal. Chem., 82 (22), 9135–9137.
7. Yang, Q., Xiang, J., Yang, S., Li, Q., Zhou, Q., Guan, A., Zhang, X., Zhang, H., Tang, Y. and Xu, G. (2010) Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: II. The binding characterization with specific intramolecular G-quadruplex and the recognizing mechanism. Nucleic Acids Res., 38, 1022-1033.
8. Yang, Q.; Xiang, J.; Yang, S.; Li, Q.; Zhou, Q.; Guan, A.; Zhang, X.; Zhang, H.; Tang, Y.; Xu, G.; (2010) Recognizing hybrid/mixed G-quadruplex in human telomeres by using a cyanine dye supramolecule with confocal laser scanning microscopy. Chin. J. Chem., 28 (7), 1126-1132.
9. Yang, Q., Xiang, J., Yang, S., Zhou, Q., Li, Q., Tang, Y. and Xu, G. (2009) Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: I. Recognizing mixed G-quadruplex in human telomeres. Chem. Commun., 1103-1105.
10. Yang, Q., Xiang, J., Li, Q., Yan, W., Zhou, Q., Tang, Y. and Xu, G. (2008) Chiral Transformation of Cyanine Dye Aggregates Induced by Small Peptides. J. Phys. Chem. B, 112, 8783-8787.
11. Zhou, Q., Li, L., Xiang, J., Tang, Y., Zhang, H., Yang, S., Li, Q., Yang, Q. and Xu, G. (2008) Screening Potential Antitumor Agents from Natural Plant Extracts by G-Quadruplex Recognition and NMR Methods. Angew. Chem.-Int. Edit., 47, 5590-5592.
12. Guan, A., Zhang, E., Xiang, J., Yang, Q., Li, Q., Sun, H., Wang, D., Zheng, Q., Xu, G. and Tang, Y. (2012) Regulating the Conformation of Methylazacalix[6]pyridine by Oligonucleotide BCL-2 2345 and Its Recognition of Hydroxymethylpiperazinofullerene. J. Phys. Chem. Lett., 3, 131-135.
13. Guan, A., Zhang, E., Xiang, J., Li, Q., Yang, Q., Li, L., Tang, Y. and Wang, M. (2011) Effects of Loops and Nucleotides in G-Quadruplexes on Their Interaction with an Azacalixarene, Methylazacalix[6]pyridine. J. Phys. Chem. B, 115, 12584-12590.
14. Zhang, X., Xiang, J., Tian, M., Yang, Q., Sun, H., Yang S,. and Tang, Y. (2009) Formation of an Intramolecular G-Quadruplex of Human Telomere Induced by Poly(l-lysine) under Salt-Deficient Conditions. J. Phys. Chem. B, 113 (21), 7662–7667.
15. Li, Q., Xiang, J., Li, X., Chen, L., Xu, X., Tang, Y., Zhou, Q., Li, L., Zhang, H., Sun, H., Guan, A., Yang, Q., Yang, S. and Xu, G. (2009) Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves. Biochimie, 91, 811-819.
16. Zhang X., Zhang H., Xiang J., Li Q., Yang Q., Shang Q., Zhang Y., Tang Y.* (2010) The binding modes of carbazole derivatives with telomere G-quadruplex. J. Mol. Struct., 982, 133-138.
17. Sun, H.; Xiang, J.; Gai, W.; Shang, Q.; Li, Q.; Guan, A.; Yang, Q.; Liu, Y.; Tang, Y.; Xu, G., (2012) Visual detection of potassium by a cyanine dye supramolecular aggregate responsive to G-quadruplex motif transition. Analyst, 137 (24), 5713-5.
18. Sun, H., Xiang, J., Zhou, Q., Yang, Q., Xu, G., Tang, Y. (2010) Temperature-sensitive supramolecules self-assembled by G-quadruplex DNA. Int. J. Biol. Macromol., 64(1), 123-125.
19. Sun, H., Xiang, J., Yang, Q., Shang, Q., Zhou, Q., Zhang, Y., Xu, G., Tang, Y. (2011) Controllable assembly and cycling conversion of various supramolecular aggregates of a cyanine dye. Appl. Phys. Lett., 98(3), 031103 - 031103-3.
20. Yang, S., Xiang, J., Yang, Q., Li, Q., Zhou, Q., Zhang, X., Tang, Y., Xu, G.. (2011) Formation of Human Telomeric G-quadruplex Structures Induced by the Quaternary Benzophenanthridine Alkaloids: Sanguinarine, Nitidine, and Chelerythrine. Chin. J. Chem., 28, 771-780.
21. Yang, S., Xiang, J., Yang, Q., Zhou, Q., Zhang, X., Li, Q., Tang, Y., Xu, G. (2011) An important functional group: Benzo[1,3]dioxole, of Alkaloids to induce the formation of human telomeric DNA G-quadruplex. Chin. Sci. Bull., 56, 613-617.
22. Yang, S., Xiang, J., Yang, Q., Zhou, Q., Zhang, X., Li, Q., Tang, Y., Xu, G. (2010) Distinct G-quadruplex structures of human telomeric DNA formed by the induction of Sanguinarine and Nitidine under salt-deficient condition. Fitoterapia, 81, 1026-1032.
23. Zhang, Y., Yang, Q., Du, H., Tang, Y., Xu, G. and Yan, W. (2008) Spectroscopic investigation on the interaction of a cyarline dye with serum albumins. Chin. J. Chem., 26, 397-401.
24. Zhou, Q.; Xiang, J.; Tang, Y.; Liao, J.; Yu, C.; Du, H.; Yang, Q. and Xu, G., (2008) Interaction of spiro[(2R,3R,4S)-4-benzyloxy-2,3-iso- propylidenedioxy-1-oxacyclopentane-5,5'-(2-nitromethylene-1,3-diazacyclohexane)] with bovine serum albumin. Pest. Biochem. Physiol., 29(1), 43-47.
25. Yang, S., Liu, Y., Yang, Q., Xiang, J., Tang, Y., Xu, G. (2011) Antitumor effect of Macleaya cordata and its molecular mechanism on inducement of human telomeric DNA to form G-quadruplex. Chin. Trad. Herb. Drugs., 42 (4), 738-742.
1. Gai, W., Yang, Q.*, Xiang, J., Yu, L., Guan, A., Li, Q., Sun, H., Shang, Q., Jiang, W., Zhang, H., Liu, Y., Wang, L., Tang, Y.* (2013) Novel Dual-Functional Regulation of a Chair-Like Antiparallel G-quadruplex on Inducing Assembly/Disassembly of Cyanine Dye. Phys. Chem. Chem. Phys., 15, 5758-5761..
2. Gai, W., Yang, Q.*, Xiang, J., Jiang, W., Li, Q., Sun, H., Guan, A., Shang, Q., Zhang, H. and Tang, Y.*, (2013) A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)]4 and cyanine dye 2, 2-diethyl-9-methyl-selenacarbocyanine bromide. Nucleic Acids Res., 41 (4), 2709-2722.
3. Gai, W., Yang, Q.*, Xiang, J., Jiang, W., Li, Q., Sun, H., Yu, L., Shang, Q., Guan, A., Zhang, H. and Tang, Y.*, (2013) A novel signal-amplified strategy based on assembly reactivation for highly specific and sensitive detection of chair-like antiparallel G-quadruplex. Analyst, 138 (3), 798-804. (Hot Article)
4. Gai, W., Yang, Q.*, Xiang, J., Sun, H., Shang, Q., Li, Q., Jiang, W., Guan, A., Zhang, H., Tang, Y.* and Xu, G., (2013) Roles of flanking sequences in the binding between unimolecular parallel-stranded G-quadruplexes and ligands. Chin. Sci. bull., 58, 731-740. (Cover Article)
5. Ng, N., Leverett, P., Hibbs, D., Yang, Q., Bulanadi, J., Wu, M., Aldrich-Wright, J.*, (2013) The antimicrobial properties of some copper(II) and platinum(II) 1,10-phenanthroline complexes. Dalton Trans. 42, 3196-3209.
6. Yang, Q., Xiang, J., Yang, S., Li, Q., Zhou, Q., Guan, A., Lin, L., Zhang, X., Zhang, H., Tang, Y. and Xu, G. (2010) Verification of Intramolecular Hybrid/Parallel G-quadruplex Structure under Physiological Condition by Using Novel Cyanine Dye H-aggregates: both in Solution and on Au Film. Anal. Chem., 82 (22), 9135–9137.
7. Yang, Q., Xiang, J., Yang, S., Li, Q., Zhou, Q., Guan, A., Zhang, X., Zhang, H., Tang, Y. and Xu, G. (2010) Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: II. The binding characterization with specific intramolecular G-quadruplex and the recognizing mechanism. Nucleic Acids Res., 38, 1022-1033.
8. Yang, Q.; Xiang, J.; Yang, S.; Li, Q.; Zhou, Q.; Guan, A.; Zhang, X.; Zhang, H.; Tang, Y.; Xu, G.; (2010) Recognizing hybrid/mixed G-quadruplex in human telomeres by using a cyanine dye supramolecule with confocal laser scanning microscopy. Chin. J. Chem., 28 (7), 1126-1132.
9. Yang, Q., Xiang, J., Yang, S., Zhou, Q., Li, Q., Tang, Y. and Xu, G. (2009) Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: I. Recognizing mixed G-quadruplex in human telomeres. Chem. Commun., 1103-1105.
10. Yang, Q., Xiang, J., Li, Q., Yan, W., Zhou, Q., Tang, Y. and Xu, G. (2008) Chiral Transformation of Cyanine Dye Aggregates Induced by Small Peptides. J. Phys. Chem. B, 112, 8783-8787.
11. Zhou, Q., Li, L., Xiang, J., Tang, Y., Zhang, H., Yang, S., Li, Q., Yang, Q. and Xu, G. (2008) Screening Potential Antitumor Agents from Natural Plant Extracts by G-Quadruplex Recognition and NMR Methods. Angew. Chem.-Int. Edit., 47, 5590-5592.
12. Guan, A., Zhang, E., Xiang, J., Yang, Q., Li, Q., Sun, H., Wang, D., Zheng, Q., Xu, G. and Tang, Y. (2012) Regulating the Conformation of Methylazacalix[6]pyridine by Oligonucleotide BCL-2 2345 and Its Recognition of Hydroxymethylpiperazinofullerene. J. Phys. Chem. Lett., 3, 131-135.
13. Guan, A., Zhang, E., Xiang, J., Li, Q., Yang, Q., Li, L., Tang, Y. and Wang, M. (2011) Effects of Loops and Nucleotides in G-Quadruplexes on Their Interaction with an Azacalixarene, Methylazacalix[6]pyridine. J. Phys. Chem. B, 115, 12584-12590.
14. Zhang, X., Xiang, J., Tian, M., Yang, Q., Sun, H., Yang S,. and Tang, Y. (2009) Formation of an Intramolecular G-Quadruplex of Human Telomere Induced by Poly(l-lysine) under Salt-Deficient Conditions. J. Phys. Chem. B, 113 (21), 7662–7667.
15. Li, Q., Xiang, J., Li, X., Chen, L., Xu, X., Tang, Y., Zhou, Q., Li, L., Zhang, H., Sun, H., Guan, A., Yang, Q., Yang, S. and Xu, G. (2009) Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves. Biochimie, 91, 811-819.
16. Zhang X., Zhang H., Xiang J., Li Q., Yang Q., Shang Q., Zhang Y., Tang Y.* (2010) The binding modes of carbazole derivatives with telomere G-quadruplex. J. Mol. Struct., 982, 133-138.
17. Sun, H.; Xiang, J.; Gai, W.; Shang, Q.; Li, Q.; Guan, A.; Yang, Q.; Liu, Y.; Tang, Y.; Xu, G., (2012) Visual detection of potassium by a cyanine dye supramolecular aggregate responsive to G-quadruplex motif transition. Analyst, 137 (24), 5713-5.
18. Sun, H., Xiang, J., Zhou, Q., Yang, Q., Xu, G., Tang, Y. (2010) Temperature-sensitive supramolecules self-assembled by G-quadruplex DNA. Int. J. Biol. Macromol., 64(1), 123-125.
19. Sun, H., Xiang, J., Yang, Q., Shang, Q., Zhou, Q., Zhang, Y., Xu, G., Tang, Y. (2011) Controllable assembly and cycling conversion of various supramolecular aggregates of a cyanine dye. Appl. Phys. Lett., 98(3), 031103 - 031103-3.
20. Yang, S., Xiang, J., Yang, Q., Li, Q., Zhou, Q., Zhang, X., Tang, Y., Xu, G.. (2011) Formation of Human Telomeric G-quadruplex Structures Induced by the Quaternary Benzophenanthridine Alkaloids: Sanguinarine, Nitidine, and Chelerythrine. Chin. J. Chem., 28, 771-780.
21. Yang, S., Xiang, J., Yang, Q., Zhou, Q., Zhang, X., Li, Q., Tang, Y., Xu, G. (2011) An important functional group: Benzo[1,3]dioxole, of Alkaloids to induce the formation of human telomeric DNA G-quadruplex. Chin. Sci. Bull., 56, 613-617.
22. Yang, S., Xiang, J., Yang, Q., Zhou, Q., Zhang, X., Li, Q., Tang, Y., Xu, G. (2010) Distinct G-quadruplex structures of human telomeric DNA formed by the induction of Sanguinarine and Nitidine under salt-deficient condition. Fitoterapia, 81, 1026-1032.
23. Zhang, Y., Yang, Q., Du, H., Tang, Y., Xu, G. and Yan, W. (2008) Spectroscopic investigation on the interaction of a cyarline dye with serum albumins. Chin. J. Chem., 26, 397-401.
24. Zhou, Q.; Xiang, J.; Tang, Y.; Liao, J.; Yu, C.; Du, H.; Yang, Q. and Xu, G., (2008) Interaction of spiro[(2R,3R,4S)-4-benzyloxy-2,3-iso- propylidenedioxy-1-oxacyclopentane-5,5'-(2-nitromethylene-1,3-diazacyclohexane)] with bovine serum albumin. Pest. Biochem. Physiol., 29(1), 43-47.
25. Yang, S., Liu, Y., Yang, Q., Xiang, J., Tang, Y., Xu, G. (2011) Antitumor effect of Macleaya cordata and its molecular mechanism on inducement of human telomeric DNA to form G-quadruplex. Chin. Trad. Herb. Drugs., 42 (4), 738-742.
Book
Shang Q., Xiang J., Yang Q. and Tang Y., Interaction Between Aggregates of Cyanine Dyes and Biomolecules, in J-Aggregates Volume 2, T. Kobayashi, Editor. 2012, World Scientific Publishing Company.
Shang Q., Xiang J., Yang Q. and Tang Y., Interaction Between Aggregates of Cyanine Dyes and Biomolecules, in J-Aggregates Volume 2, T. Kobayashi, Editor. 2012, World Scientific Publishing Company.
Patents
International Patent (PCT)
1. A method for Leukemia diagnosis and related kit and system. PCT/CN2013/071728
Granted Chinese Invention Patents
2. Novel method about cyanine dye in verifying specific G-quadruplex structure DNA. ZL 200810112394
Applied Chinese Invention Patents
3. Application of supramolecular assembly in verifying specific G-quadruplex structure DNA. 200810112393
4. Kit applied in Leukemia diagnosis. 201210041112.2
5. System applied in Leukemia diagnosis. 201210041131.5
6. New application of cyanine dye. 201210164349.X
7. New application of cyanine dye. 201210164341.9
8. System applied in breast cancer diagnosis. 201210164367.8
9. Kit and system applied in Leukemia diagnosis. 201210164310.8
10. A method for Potassium concentration detection. 201210206227.2
11. Kit and system applied in Potassium concentration detection. 201210207722.5
12. A method for Potassium concentration detection. 201210205843.6
13. Kit applied in Potassium concentration detection. 201210205861.4
14. A method for the ratio of sodium/potassium detection and related kit and system. 201210553125.8
15. A method for the ratio of sodium/potassium detection and related kit and system. 201210553784.1
16. A method for urine microalbumin detection and related kit and system. 201310027507.1
17. A method and kit for urine microalbumin detection. 201310027719.X
International Patent (PCT)
1. A method for Leukemia diagnosis and related kit and system. PCT/CN2013/071728
Granted Chinese Invention Patents
2. Novel method about cyanine dye in verifying specific G-quadruplex structure DNA. ZL 200810112394
Applied Chinese Invention Patents
3. Application of supramolecular assembly in verifying specific G-quadruplex structure DNA. 200810112393
4. Kit applied in Leukemia diagnosis. 201210041112.2
5. System applied in Leukemia diagnosis. 201210041131.5
6. New application of cyanine dye. 201210164349.X
7. New application of cyanine dye. 201210164341.9
8. System applied in breast cancer diagnosis. 201210164367.8
9. Kit and system applied in Leukemia diagnosis. 201210164310.8
10. A method for Potassium concentration detection. 201210206227.2
11. Kit and system applied in Potassium concentration detection. 201210207722.5
12. A method for Potassium concentration detection. 201210205843.6
13. Kit applied in Potassium concentration detection. 201210205861.4
14. A method for the ratio of sodium/potassium detection and related kit and system. 201210553125.8
15. A method for the ratio of sodium/potassium detection and related kit and system. 201210553784.1
16. A method for urine microalbumin detection and related kit and system. 201310027507.1
17. A method and kit for urine microalbumin detection. 201310027719.X